Cohen Klassen scored twice in a span of 52 seconds midway through the first period to put Regina in front for good. Klassen opened the scoring at 5:42 on a pass from Dayton Deschamps, and Luke Cozens answered for Medicine Hat at 6:50, his fifth of the season, assisted by Josh Evaschesen and Dayton Reschny.
Klassen's second of the night, assisted by Zach Moore and Maddox Schultz at 7:42, was ruled the game-winning goal. Liam Pue added a power-play marker at 10:06 and Mathis Paull scored unassisted at 11:51 to make it 4-1 after 20 minutes.
Pue scored his second power-play goal of the game at 19:20 of the second period, and Zachary Lansard added another at 15:57 to complete the Pats' six-goal night. Regina finished two for four on the power play; Medicine Hat went zero for four.
Tigers starter Carter Casey stopped four of seven shots before being replaced at 10:06 of the first period. Cash Christie made 19 saves on 22 shots the rest of the way. Taylor Tabashniuk turned aside 33 of 34 shots to earn first-star honours and the win for Regina.
Medicine Hat was outshot 29-34 overall. Brayden Holberton received a 10-minute misconduct in the third period; the Tigers finished with 20 penalty minutes.
With the loss, the Tigers fall to 4-3-1 for nine points, third in the Central Division. They are on a three-game losing streak. Regina improves to 4-3-1 for nine points.
Medicine Hat returns to action Saturday when it visits the Brandon Wheat Kings at Assiniboine Credit Union Place. Puck drop is at 6 p.m. CDT.